You cannot right-click a suspicious file in Windows Explorer and scan it immediately. You must open the portable app, navigate manually to the file path, or run a full directory scan.
If you need free, basic removal, Malwarebytes Portable is superior. However, if you are fighting browser hijackers (e.g., Search Marquis, MySearch) or fake antivirus software that hides deep in the registry, SpyHunter 5 Portable’s Dynamic OSR gives it an edge—but you pay for it. spyhunter 5 portable