Developed through rational drug design, KUF-13046 was engineered to address the limitations of first-generation compounds, namely poor bioavailability and off-target toxicity. Preliminary data suggests that KUF-13046 exhibits high selectivity and metabolic stability, making it an ideal candidate for preclinical investigation.
While "KUF" is the IATA code for Kurumoch International Airport in Samara, Russia, the "13046" suffix does not correspond to any official flight numbers or terminal gate designations currently in use. KUF-13046
✅ Novel MOA: Targets the acetyltransferase domain directly, offering an alternative to HDAC inhibitors. ✅ Selectivity: Designed to minimize off-target effects associated with broader epigenetic drugs. ✅ Therapeutic Reach: Shows promise in preclinical models for hematological malignancies and solid tumors. Developed through rational drug design