The biggest mechanical change is the "Reaction Log." In previous versions, the female lead (the protagonist’s roommate/sister figure, depending on your interpretation) had a limited set of responses. In V2.0, her AI uses a hidden "trust/paranoia" matrix. She will now remember specific actions you took three in-game days ago. She will comment on objects you moved. She will lock doors if you invade her privacy too often. This system makes feel less like a simulator and more like a surveillance thriller. You are being watched by the very character you are trying to influence.
“The first thing Elias noticed about being dead was how quiet the advertisements were. The second thing he noticed was the blinking cursor in the corner of his vision, waiting for a command he didn't know how to give.” Lost Life V2.0