Prn-4011 __full__ Page

PRN-4011 acts as a potent activator of the Nrf2-ARE (Antioxidant Response Element) signaling pathway. By disrupting the Keap1-Nrf2 interaction, PRN-4011 allows Nrf2 to translocate to the nucleus, where it upregulates the expression of over 200 cytoprotective genes, including:

In acute neurological events (such as stroke or traumatic brain injury), neurons suffer from energy failure. This leads to an influx of calcium ions, the generation of reactive oxygen species (ROS), and ultimately, programmed cell death (apoptosis). PRN-4011 is hypothesized to intervene at this juncture through three distinct pathways: prn-4011