: Detailed instructions for performing broth microdilution and agar disk diffusion for specific "non-standard" organisms.
Provides specific interpretive criteria (breakpoints) for difficult-to-treat opportunistic pathogens like Pseudomonas species other than P. aeruginosa (POPA) and Achromobacter .
The document notes that the guidelines may not cover all possible scenarios and that ongoing research may lead to changes in testing methods and interpretive criteria.
document, titled Methods for Antimicrobial Dilution and Disk Susceptibility Testing of Infrequently Isolated or Fastidious Bacteria
In the intricate world of clinical microbiology, precision is not just a goal—it is a requirement for patient survival. Laboratories worldwide face a daily challenge: how to accurately determine the susceptibility of fastidious and anaerobic bacteria to antimicrobial agents. These organisms, which include Streptococcus pneumoniae , Haemophilus influenzae , and various Bacteroides species, do not grow reliably under standard testing conditions.
CLSI M45 is a document that provides guidelines for the performance and interpretation of antimicrobial susceptibility testing (AST) of fungi, including yeast and molds. The document is intended for clinical microbiologists, laboratory professionals, and healthcare providers.
